Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | CPT2 | P23786 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12791163 | 0.80 | CHRM1 (0.38) | NAMPT | |
| SCHEMBL13644765 | 0.78 | RIPK1 (0.36) | NAMPTRIPK1 | |
| SCHEMBL14626884 | 0.78 | NAMPT (0.33) | NAMPT | |
| SCHEMBL1697325 | 0.78 | NAMPT (0.33) | NAMPT | |
| SCHEMBL4954683 | 0.78 | NPC1 (0.32) | HPGD | |
| SCHEMBL3763074 | 0.78 | NPC1 (0.36) | HPGDKDM4EATMTDP1 | |
| SCHEMBL17662444 | 0.76 | ALDH1A1 (0.33) | NAMPT | |
| SCHEMBL22021683 | 0.76 | NAMPT (0.32) | NAMPT | |
| SCHEMBL14982939 | 0.76 | NAMPT (0.32) | NAMPT | |
| SCHEMBL1019081 | 0.76 | RIPK1 (0.32) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906534-B1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | GRUENENTHAL GMBH (DE) | 2016-12-07 | — | — | EP | disclosed |
| US-9302988-B2 | Fluoromethyl-substituted pyrrole carboxamides | Grünenthal GmbH (DE) | 2016-04-05 | — | — | US | disclosed |
| EP-2906534-A1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | Grünenthal GmbH (DE) | 2015-08-19 | — | — | EP | disclosed |
| US-20140066426-A1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | GRUENENTHAL GMBH (DE) | 2014-03-06 | — | — | US | disclosed |
| WO-2014032801-A1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | Grünenthal GmbH (DE) | 2014-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066426-A1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | TRPV1, CACNA1B, CACNA1G | NAMPT 2189/4885HPGD 1329/4885RIPK1 2951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.