Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | NPY4R | P50391 | 6/20 | 0.32 |
| ▸ | NPY1R | P25929 | 5/20 | 0.32 |
| ▸ | NPY2R | P49146 | 4/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | OTC | P00480 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL14841994 | 0.95 | PRCP (0.38) | PRCPMAPK8MAPK9MAPK10NOS2 | |
| Arginine SCHEMBL23248653 | 0.95 | PRCP (0.38) | PRCPMAPK8MAPK9MAPK10NOS2 | |
| Arginine SCHEMBL11905093 | 0.95 | PRCP (0.38) | PRCPMAPK8MAPK9MAPK10NOS2 | |
| Arginine SCHEMBL25168271 | 0.93 | PRCP (0.36) | PRCPMAPK8MAPK9MAPK10NOS2 | |
| Arginine SCHEMBL11905292 | 0.93 | PRCP (0.35) | PRCPNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL28419523 | 0.93 | PRCP (0.38) | PRCPNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL1697257 | 0.93 | PRCP (0.38) | PRCPNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL2501111 | 0.92 | PRCP (0.36) | PRCPMAPK8MAPK9MAPK10NOS2 | |
| Arginine SCHEMBL17982370 | 0.92 | PRCP (0.36) | PRCPMAPK8MAPK9MAPK10NOS2 | |
| Arginine SCHEMBL29157307 | 0.92 | PRCP (0.35) | PRCPNPY4RNPY1RNPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10350268-B2 | Medical use of the radical scavenger and antioxidant alpha-1-microglobulin | A1M PHARMA AB (SE) | 2019-07-16 | — | — | US | disclosed |
| EP-2638915-B1 | Medical use of the radical scavenger and antioxidant alpha-1-microglobulin | A1M PHARMA AB (SE) | 2016-10-19 | — | — | EP | disclosed |
| EP-2313106-B1 | MEDICAL USE OF THE RADICAL SCAVENGER AND ANTIOXIDANT ALPHA-1-MICROGLOBULIN | A1M PHARMA AB (SE) | 2016-03-30 | — | — | EP | disclosed |
| EP-2638915-A1 | Medical use of the radical scavenger and antioxidant alpha-1-microglobulin | A1M Pharma AB (SE) | 2013-09-18 | — | — | EP | disclosed |
| US-20110190208-A1 | MEDICAL USE OF THE RADICAL SCAVENGER AND ANTIOXIDANT ALPHA-1-MICROGLOBULIN | Guard Therapeutics International AB (SE) | 2011-08-04 | — | — | US | disclosed |
| EP-2313106-A2 | MEDICAL USE OF THE RADICAL SCAVENGER AND ANTIOXIDANT ALPHA-1-MICROGLOBULIN | Akerström, Bo (SE) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010006809-A2 | MEDICAL USE OF THE RADICAL SCAVENGER AND ANTIOXIDANT ALPHA-1-MICROGLOBULIN | AKERSTROEM BO (SE) | 2010-01-21 | — | — | WO | disclosed |