Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | CTSG | P08311 | 2/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200960 | 0.84 | ELANE (0.45) | ELANEHTR2CSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2207568 | 0.81 | HTR2C (0.46) | ELANEHTR2CSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3610882 | 0.80 | SMN1; SMN2 (0.46) | ELANEHTR2CSMN1; SMN2NPC1RAB9A | |
| SCHEMBL15500345 | 0.78 | ELANE (0.44) | ELANEHTR2CHCRTR2SMN1; SMN2NPC1 | |
| SCHEMBL12431658 | 0.77 | ELANE (0.44) | ELANEHTR2CHCRTR2SMN1; SMN2NPC1 | |
| SCHEMBL12431659 | 0.73 | SMN1; SMN2 (0.40) | ELANEHTR2CSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4602471 | 0.72 | PREP (0.54) | SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL22555204 | 0.72 | ELANE (0.50) | ELANESMN1; SMN2NPC1RAB9AF2 | |
| SCHEMBL22208070 | 0.72 | ELANE (0.50) | ELANESMN1; SMN2NPC1RAB9AF2 | |
| SCHEMBL1604782 | 0.72 | FKBP1A (0.41) | ELANEHTR2CSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912994-B1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | disclosed |