Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2768429 | 0.84 | PREP (0.60) | PREPTSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL11489453 | 0.83 | TMEM97 (0.53) | PREPTSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL14836799 | 0.83 | CTSK (0.58) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7284521 | 0.83 | SMN1; SMN2 (0.54) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL19360224 | 0.81 | TSHR (0.59) | PREPTSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL14893288 | 0.81 | TSHR (0.64) | PREPTSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL847403 | 0.81 | TSHR (0.64) | PREPTSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL11560321 | 0.80 | FKBP1A (0.57) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL15512974 | 0.80 | ELANE (0.46) | PREPTSHRL3MBTL1KDM4ELMNA | |
| SCHEMBL30845587 | 0.80 | PREP (0.53) | PREPTSHRL3MBTL1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912994-A1 | ADENINE DERIVATIVES | Merck Patent GmbH (DE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007017069-A1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-15 | — | — | WO | disclosed |