Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20329117 | 0.81 | ELANE (0.48) | ELANESMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL2202904 | 0.81 | ELANE (0.48) | ELANESMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL28387613 | 0.81 | ELANE (0.48) | ELANESMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL4602471 | 0.80 | PREP (0.54) | SMN1; SMN2NPC1RAB9ACYP2C19PREP | |
| SCHEMBL12849555 | 0.79 | HTR2C (0.56) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL22184883 | 0.78 | HTR2C (0.54) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL22175019 | 0.77 | HTR2C (0.53) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL8290690 | 0.77 | SMN1; SMN2 (0.48) | ELANESMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL15743850 | 0.77 | SMN1; SMN2 (0.48) | ELANESMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL3600152 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912994-B1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | disclosed |