Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28458675 | 0.98 | TRPV1 (0.49) | NOS1AXLTRPV1CDK8CLK4 | |
| SCHEMBL12842830 | 0.87 | HTR6 (0.58) | NOS1AXLALDH1A1 | |
| SCHEMBL17738867 | 0.81 | ALDH1A1 (0.48) | TRPV1CLK4IDO1ROCK2ROCK1 | |
| SCHEMBL17738862 | 0.81 | TRPV1 (0.54) | TRPV1CDK8CLK4ALDH1A1 | |
| SCHEMBL17738491 | 0.81 | TRPV1 (0.46) | NOS1AXLTRPV1CDK8CLK4 | |
| SCHEMBL27804607 | 0.81 | TRPV1 (0.58) | TRPV1CDK8CLK4METAP2 | |
| SCHEMBL1537810 | 0.79 | DRD4 (0.66) | TRPV1ALDH1A1 | |
| SCHEMBL17738539 | 0.79 | ALDH1A1 (0.52) | TRPV1CLK4IDO1POLBALDH1A1 | |
| SCHEMBL17739091 | 0.79 | TRPV1 (0.58) | TRPV1CDK8CLK4ALDH1A1 | |
| SCHEMBL4788214 | 0.79 | NOS1 (0.41) | NOS1AXLTRPV1CDK8CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892892-A1 | IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR!THE TREATMENT OF CANCER | Janssen Pharmaceutica N.V. (BE) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014039769-A1 | IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR|THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-13 | — | — | WO | disclosed |