Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Amikacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.98 |
| ▸ | RAD52 | P43351 | 1/20 | 0.98 |
| ▸ | GJB2 | P29033 | 2/20 | 0.66 |
| ▸ | GJA1 | P17302 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amikacin SCHEMBL15515830 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL20516499 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL2637141 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL15263372 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL23308753 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL20522644 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL24437395 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL13260939 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL20516498 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL15263403 | 1.00 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4633677-A1 | VIROPORINS BLOCKERS/INHIBITORS AS ANTI-INFLUENZA AGENTS | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) | 2025-10-22 | — | — | EP | disclosed |
| US-20240299379-A1 | COMPOSITIONS OF CLOFAZIMINE AND AMIKACIN FOR PULMONARY ADMINISTRATION IN THE TREATMENT OF RESPIRATORY DISEASES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2024-09-12 | — | — | US | disclosed |
| WO-2024127407-A1 | VIROPORINS BLOCKERS/INHIBITORS AS ANTI-INFLUENZA AGENTS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2024-06-20 | — | — | WO | disclosed |
| WO-2022256464-A1 | COMPOSITIONS OF CLOFAZIMINE AND AMIKACIN FOR PULMONARY ADMINISTRATION IN THE TREATMENT OF RESPIRATORY DISEASES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-12-08 | — | — | WO | disclosed |
| WO-2018182515-A1 | METHODS OF MODIFYING FUNGI AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-10-04 | — | — | WO | disclosed |
| US-9539222-B2 | Methods to inhibit intracellular growth of bacteria and to treat bacteria-mediated diseases | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-01-10 | — | — | US | disclosed |
| US-20150209308-A1 | METHODS TO INHIBIT INTRACELLULAR GROWTH OF BACTERIA AND TO TREAT BACTERIA-MEDIATED DISEASES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH | 2015-07-30 | — | — | US | disclosed |
| WO-2014039011-A1 | METHODS TO INHIBIT INTRACELLULAR GROWTH OF BACTERIA AND TO TREAT BACTERIA-MEDIATED DISEASES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-03-13 | — | — | WO | disclosed |