Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30799059 | 0.95 | L3MBTL1 (0.65) | L3MBTL1CDC7PLK4AURKAMAPK13 | |
| SCHEMBL31512198 | 0.94 | L3MBTL1 (0.68) | L3MBTL1CDC7PLK4AURKAMAPK13 | |
| SCHEMBL27165584 | 0.94 | L3MBTL1 (0.68) | L3MBTL1CDC7PLK4AURKAMAPK13 | |
| SCHEMBL7935783 | 0.85 | SIGMAR1 (0.46) | L3MBTL1HTR2CSIGMAR1 | |
| SCHEMBL14047566 | 0.82 | HTR2C (0.41) | L3MBTL1HTR2CFAAHKMT2ASIGMAR1 | |
| SCHEMBL24732719 | 0.81 | L3MBTL1 (0.58) | L3MBTL1CDC7PLK4AURKAMAPK13 | |
| SCHEMBL13181473 | 0.81 | L3MBTL1 (0.58) | L3MBTL1CDC7PLK4AURKAMAPK13 | |
| SCHEMBL15152924 | 0.81 | L3MBTL1 (0.58) | L3MBTL1CDC7PLK4AURKAMAPK13 | |
| SCHEMBL11010729 | 0.81 | L3MBTL1 (0.58) | L3MBTL1CDC7PLK4AURKAMAPK13 | |
| SCHEMBL2720932 | 0.81 | L3MBTL1 (0.58) | L3MBTL1CDC7PLK4AURKAMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249125-B2 | Pyrazole derivatives as p38 MAP inhibitors | RESPIVERT LIMITED (GB) | 2016-02-02 | — | — | US | disclosed |
| US-9249125-B2 | Pyrazole derivatives as p38 MAP inhibitors | RESPIVERT LIMITED (GB) | 2016-02-02 | — | — | US | disclosed |
| US-9249125-B2 | Pyrazole derivatives as p38 MAP inhibitors | RESPIVERT LIMITED (GB) | 2016-02-02 | — | — | US | disclosed |
| US-20150203475-A1 | PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS | TOPIVERT PHARMA LIMITED (GB) | 2015-07-23 | — | — | US | disclosed |
| US-20150203475-A1 | PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS | TOPIVERT PHARMA LIMITED (GB) | 2015-07-23 | — | — | US | disclosed |
| US-20150203475-A1 | PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS | TOPIVERT PHARMA LIMITED (GB) | 2015-07-23 | — | — | US | disclosed |
| EP-2890693-A1 | PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS | Respivert Limited (GB) | 2015-07-08 | — | — | EP | disclosed |
| WO-2014033448-A1 | PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS | RESPIVERT LIMTED (GB) | 2014-03-06 | — | — | WO | disclosed |
| WO-2014033448-A1 | PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS | RESPIVERT LIMTED (GB) | 2014-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203475-A1 | PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS | SYK, FYN, MAPK1 | L3MBTL1 4380/4885CDC7 1923/4885PLK4 1227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.