Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.55 |
| ▸ | NPC1 | O15118 | 11/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3429872 | 0.80 | MEN1 (0.38) | RAB9ANPC1HPGDHSD17B10ALDH1A1 | |
| SCHEMBL4871397 | 0.70 | KDM4E (0.69) | RAB9ANPC1HPGDTSHRHSD17B10 | |
| SCHEMBL6689179 | 0.69 | APP (0.71) | RAB9ANPC1HPGDTSHRHSD17B10 | |
| SCHEMBL3429916 | 0.69 | RAB9A (1.00) | RAB9ANPC1HPGDTSHRHSD17B10 | |
| SCHEMBL14465536 | 0.68 | RAB9A (0.73) | RAB9ANPC1HPGDTSHRHSD17B10 | |
| SCHEMBL16486187 | 0.65 | ALDH1A1 (0.57) | RAB9ANPC1HPGDTSHRHSD17B10 | |
| SCHEMBL18977333 | 0.65 | P2RX7 (0.43) | RAB9ANPC1HPGDTSHRHSD17B10 | |
| SCHEMBL17196547 | 0.65 | P2RX7 (0.46) | RAB9ANPC1HPGDTSHRHSD17B10 | |
| SCHEMBL11812106 | 0.63 | RAB9A (0.70) | RAB9ANPC1HPGDTSHRHSD17B10 | |
| SCHEMBL122784 | 0.63 | APP (0.81) | RAB9ANPC1HPGDTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230277574-A1 | TREATMENT OF HEARING LOSS | MASSACHUSETTS EYE AND EAR INFIRMARY | 2023-09-07 | — | — | US | disclosed |
| EP-3212773-B1 | EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2021-09-15 | — | — | EP | disclosed |
| EP-2892523-B1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2019-05-01 | — | — | EP | disclosed |
| EP-3212773-A1 | EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR | Massachusetts Eye & Ear Infirmary (US) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016069906-A1 | EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2016-05-06 | — | — | WO | disclosed |
| EP-2892523-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | Massachusetts Eye & Ear Infirmary (US) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014039908-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2014-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230277574-A1 | TREATMENT OF HEARING LOSS | HES1, NOTCH1, NOTCH4 | RAB9A 1434/4885NPC1 1607/4885HPGD 4083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.