SCHEMBL1551923

SCHEMBL1551923

Oc1ccccc1Cc1[c]cccc1

nearest known ligand 0.58

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSPA5 P11021 1/20 0.58
KEAP1 Q14145 1/20 0.47
TSHR P16473 2/20 0.42
CYP2D6 P10635 1/20 0.42
HIF1A Q16665 1/20 0.42
TAAR1 Q96RJ0 1/20 0.41
AKR1B1 P15121 1/20 0.41
CA12 O43570 6/20 0.39
CA2 P00918 6/20 0.39
IDO1 P14902 2/20 0.39
CA9 Q16790 5/20 0.38
MPO P05164 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
KDM4E B2RXH2 1/20 0.37
HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15031 0.78 CALM1 (0.32)
SCHEMBL5852719 0.78 HSPA5 (0.60) HSPA5KEAP1TSHRCYP2D6HIF1A
SCHEMBL4599279 0.77 GABRA1 (0.57) HSPA5TSHR
SCHEMBL972443 0.77 TRPA1 (0.44) HSPA5KEAP1KDM4EHSD17B10
SCHEMBL10396737 0.76
SCHEMBL1345567 0.76 IDO1 (0.43) CYP2D6TAAR1IDO1
SCHEMBL3237939 0.76 TAAR1 (0.41) TSHRTAAR1
SCHEMBL16654780 0.76 CYP3A4 (0.40)
SCHEMBL2871136 0.76 TAAR1 (0.42) TAAR1IDO1KDM4E
SCHEMBL29357407 0.75 HSPA5 (1.00) HSPA5KEAP1TSHRCYP2D6HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE46830-E1 Method for solid phase peptide synthesis POLYPEPTIDE LABORATORIES HOLDING (PPL) AB (SE) 2018-05-08 US disclosed
US-20170283478-A1 PROCESS FOR PREPARATION OF LIRAGLUTIDE DR. REDDY'S LABORATORIES LIMITED (IN) 2017-10-05 US disclosed
WO-2016005960-A1 PROCESS FOR PREPARATION OF LIRAGLUTIDE DR. REDDY'S LABORATORIES LIMITED (IN) 2016-01-14 WO disclosed
US-9040480-B2 Synthesis of glucagon-like peptide LONZA AG (CH) 2015-05-26 US disclosed
US-20130324699-A1 SYNTHESIS OF GLUCAGON-LIKE PEPTIDE LONZA AG (CH) 2013-12-05 US disclosed
US-8445433-B2 Synthesis of glucagon-like peptide LONZA AG (CH) 2013-05-21 US disclosed
US-7939629-B2 Method for solid phase peptide synthesis LONZA AG (CH) 2011-05-10 US disclosed
EP-1987052-B1 SYNTHESIS OF GLUCAGON-LIKE PEPTIDES LONZA AG (CH) 2011-04-27 EP disclosed
US-20090292106-A1 SYNTHESIS OF GLUCAGON-LIKE PEPTIDE POLYPEPTIDE LABORATORIES HOLDING (PPL) AB (SE) 2009-11-26 US disclosed
US-20080287648-A1 Method for Solid Phase Peptide Synthesis LONZA AG (CH) 2008-11-20 US disclosed
WO-2007090496-A1 SYNTHESIS OF GLUCAGON-LIKE PEPTIDE LONZA AG (CH) 2007-08-16 WO disclosed
EP-1794180-A1 PEPTIDE CYCLISATION LONZA AG (CH) 2007-06-13 EP disclosed
EP-1737889-A1 METHOD FOR SOLID PHASE PEPTIDE SYNTHESIS LONZA AG (CH) 2007-01-03 EP disclosed
WO-2006032457-A9 PEPTIDE CYCLISATION LONZA AG (CH) 2006-05-26 WO disclosed
WO-2006045503-A1 METHOD FOR SOLID PHASE PEPTIDE SYNTHESIS LONZA AG (CH) 2006-05-04 WO disclosed
WO-2006032457-A1 PEPTIDE CYCLISATION LONZA AG (CH) 2006-03-30 WO disclosed
EP-0805796-A1 CELL ADHESION INHIBITORS BIOGEN, INC. (US) 1997-11-12 EP disclosed
WO-1996022966-A1 CELL ADHESION INHIBITORS BIOGEN, INC. (US) 1996-08-01 WO disclosed
EP-0051023-A1 Derivatives of the benzoyl and alpha hydroxybenzyl-phenyl osides family, method for their preparation and their therapeutic application SOCIETE DE RECHERCHES INDUSTRIELLES S.O.R.I. Société anonyme dite: (FR) 1982-05-05 EP disclosed
US-4107137-A Phenolic antioxidants for synthetic polymers SOCIETE FRANCAISE D'ORGANO SYNTHESE (FR) 1978-08-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090292106-A1 SYNTHESIS OF GLUCAGON-LIKE PEPTIDE GLP1R, IAPP, GIPR HSPA5 1507/4885KEAP1 2734/4885TSHR 293/4885
US-20080287648-A1 Method for Solid Phase Peptide Synthesis HM13, VIP, HIRA HSPA5 1293/4885KEAP1 2627/4885TSHR 1224/4885
US-20130324699-A1 SYNTHESIS OF GLUCAGON-LIKE PEPTIDE GLP1R, IAPP, GIPR HSPA5 1507/4885KEAP1 2734/4885TSHR 293/4885
US-20170283478-A1 PROCESS FOR PREPARATION OF LIRAGLUTIDE GLP1R, IAPP, GCG HSPA5 1519/4885KEAP1 3840/4885TSHR 138/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.