Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | GRN | P28799 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186234 | 0.73 | EGLN1 (0.44) | KMT2ALMNANPC1RAB9ACNR1 | |
| SCHEMBL15519831 | 0.70 | KMT2A (0.40) | KMT2ALMNACNR1CNR2EGLN1 | |
| SCHEMBL415320 | 0.69 | ALDH1A1 (0.51) | KMT2ALMNARAB9A | |
| SCHEMBL16835123 | 0.69 | NOTUM (0.42) | LMNANPC1RAB9AEGLN1 | |
| SCHEMBL18611527 | 0.68 | GRIA1 (0.40) | CNR1CNR2PARP1PARP2KDM5A | |
| SCHEMBL19120266 | 0.67 | TRPV4 (0.35) | CNR1CNR2DHFRGRIN2BGRIA1 | |
| SCHEMBL415272 | 0.67 | TRPV4 (0.37) | KMT2ALMNACNR1CNR2EGLN1 | |
| SCHEMBL6034668 | 0.67 | CYP11B1 (0.34) | RAB9ACNR1CNR2GRIA1 | |
| SCHEMBL25227025 | 0.67 | MYC (0.36) | KMT2ALMNACNR1CNR2 | |
| SCHEMBL30174170 | 0.67 | MYC (0.36) | KMT2ALMNACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2862860-B1 | 1,3-OXAZOLIDINE OR 1,3-OXAZINANE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO LTD (JP) | 2016-12-21 | — | — | EP | disclosed |
| US-9266870-B2 | Heteroaromatic methyl cyclic amine derivative | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2016-02-23 | — | — | US | disclosed |
| US-20150183768-A1 | HETEROAROMATIC METHYL CYCLIC AMINE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2015-07-02 | — | — | US | disclosed |
| EP-2862860-A1 | HETEROAROMATIC METHYL CYCLIC AMINE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2015-04-22 | — | — | EP | disclosed |
| US-20140081025-A1 | HETEROAROMATIC RING DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2014-03-20 | — | — | US | disclosed |
| EP-2708537-A1 | HETEROAROMATIC RING DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2014-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140081025-A1 | HETEROAROMATIC RING DERIVATIVE | HCRTR2, HCRTR1, HTT | KMT2A 419/4885LMNA 4559/4885NPC1 610/4885 |
| US-20150183768-A1 | HETEROAROMATIC METHYL CYCLIC AMINE DERIVATIVE | HCRTR2, HCRTR1, HTR2B | KMT2A 151/4885LMNA 4564/4885NPC1 1120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.