Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4812393 | 0.79 | DHODH (0.46) | RAB9AKMT2AMAPK1TDP1SLC6A2 | |
| SCHEMBL22758029 | 0.78 | TDP1 (0.40) | RAB9ANPC1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL257906 | 0.77 | TDP1 (0.48) | RAB9ANPC1KMT2AMAPK1TDP1 | |
| SCHEMBL12602988 | 0.75 | ALDH1A1 (0.47) | RAB9ANPC1KMT2AMAPK1TDP1 | |
| SCHEMBL2592375 | 0.74 | LMNA (0.46) | RAB9ANPC1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL16342895 | 0.74 | KMT2A (0.58) | RAB9ANPC1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL15211084 | 0.73 | RAB9A (0.50) | RAB9ANPC1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL6068448 | 0.73 | TDP1 (0.59) | RAB9ANPC1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL25560288 | 0.73 | ALDH1A1 (0.41) | RAB9AKMT2AMAPK1TDP1SLC6A2 | |
| SCHEMBL17792724 | 0.72 | ALDH1A1 (0.51) | RAB9ANPC1KMT2AMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137371-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-05-18 | — | — | US | disclosed |
| US-9598371-B2 | Arylalkylamine compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-03-21 | — | — | US | disclosed |
| US-20160075655-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-03-17 | — | — | US | disclosed |
| US-9227919-B2 | Arylalkylamine compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2016-01-05 | — | — | US | disclosed |
| US-20150239827-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2015-08-27 | — | — | US | disclosed |
| EP-2888225-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | Lupin Limited (IN) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014033604-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2014-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137371-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR2, ORAI1 | RAB9A 1333/4885NPC1 547/4885KMT2A 3280/4885 |
| US-20150239827-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR2, ORAI1 | RAB9A 1333/4885NPC1 547/4885KMT2A 3280/4885 |
| US-20160075655-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR2, ORAI1 | RAB9A 1333/4885NPC1 547/4885KMT2A 3280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.