Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 3/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30923019 | 1.00 | TSHR (0.64) | TSHRMAPK1CA1CA2MMP1 | |
| SCHEMBL16712984 | 0.85 | TSHR (0.56) | TSHRMAPK1CA1CA2MMP1 | |
| SCHEMBL545300 | 0.83 | VCAM1 (0.61) | TSHRMAPK1CYP3A4ALDH1A1TDP1 | |
| SCHEMBL9362733 | 0.81 | TSHR (0.51) | TSHRMAPK1CA1CA2MMP1 | |
| SCHEMBL5857928 | 0.81 | PDE7A (0.72) | TSHRMAPK1CA1CA2MMP1 | |
| SCHEMBL29577003 | 0.80 | TSHR (0.56) | TSHRMAPK1CYP3A4ALDH1A1NPSR1 | |
| SCHEMBL213758 | 0.80 | TSHR (0.56) | TSHRMAPK1CYP3A4ALDH1A1NPSR1 | |
| SCHEMBL68980 | 0.78 | GPR35 (0.67) | TSHRMAPK1CYP3A4ALDH1A1TDP1 | |
| SCHEMBL29398960 | 0.78 | TSHR (1.00) | TSHRMAPK1CA1CA2MMP1 | |
| SCHEMBL29479746 | 0.78 | GPR35 (0.67) | TSHRMAPK1CYP3A4ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 308 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025120654-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF TIVOZANIB HYDROCHLORIDE HYDRATE | NATCO PHARMA LIMITED (IN) | 2025-06-12 | — | — | WO | claimed |
| CN-118702085-A | Method for regulating specific surface area of carbon material | 三明学院 | 2024-09-27 | — | — | CN | claimed |
| CN-113683511-A | Synthesis method of 2-chloro-4-trifluoromethylphenyl-4 '-nitro-3' -ethoxy phenyl ether | 广东立威化工有限公司 | 2021-11-23 | — | — | CN | claimed |
| CN-109912424-B | Method for hydrolyzing nitroaniline substances into phenol | 浙江大学 | 2020-08-07 | — | — | CN | claimed |
| CN-111377865-A | Preparation method of high-purity lenvatinib | 北京启慧生物医药有限公司 | 2020-07-07 | — | — | CN | claimed |
| CN-109776498-B | Preparation method of cilostazol | 浙江永宁药业股份有限公司 | 2020-04-07 | — | — | CN | claimed |
| CN-109776498-A | A kind of preparation method of Cilostazol | 浙江永宁药业股份有限公司 | 2019-05-21 | — | — | CN | claimed |
| CN-105859559-A | Production method of 3-ethoxy-4-nitrophenol | 盐城工学院 | 2016-08-17 | — | — | CN | claimed |
| JP-8019095-B2 | — | — | 1996-02-28 | — | — | JP | claimed |
| EP-0302874-B1 | INDOLOQUINONE COMPOUNDS | SPECKAMP, Willem Nico (NL) | 1992-12-02 | — | — | EP | claimed |
| EP-0302874-A1 | INDOLOQUINONE COMPOUNDS. | SPECKAMP WILLEM NICO (NL) | 1989-02-15 | — | — | EP | claimed |
| WO-1987006227-A2 | INDOLOQUINONE COMPOUNDS | JOUHAR AKBAR JAN (GB) | 1987-10-22 | — | — | WO | claimed |
| WO-2026087442-A1 | AMINO-IMIDAZOLE ANTIBACTERIAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2026-04-30 | — | — | WO | disclosed |
| EP-4083031-B1 | QUINOLINE COMPOUND AND APPLICATION THEREOF AS FGFR4 KINASE INHIBITOR | SKYRUN PHARMA CO LTD (CN) | 2026-04-22 | — | — | EP | disclosed |
| US-12570672-B2 | Macrocyclic compounds and methods of use | AMGEN INC. | 2026-03-10 | — | — | US | disclosed |
| US-20250304599-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2025-10-02 | — | — | US | disclosed |
| EP-0001734-A2 | Imide groups containing polymers, processes for their preparation and their uses for making various objects | RHONE-POULENC INDUSTRIES (FR) | 1979-05-02 | — | — | EP | disclosed |
| US-4102924-A | REACTING ACYLAMINO-ARYLS WITH HALO-ARYLS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-07-25 | — | — | US | disclosed |
| US-4059627-A | HYDROGENATION OF CHLORINATED NITRO AROMATIC, NOBLE METAL CATALYST, THIOETHER | BAYER AKTIENGESELLSCHAFT (DT) | 1977-11-22 | — | — | US | disclosed |
| US-4020084-A | Cyclic aminals of aromatic aldehydes | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12570672-B2 | Macrocyclic compounds and methods of use | KRAS, NRAS, BRAF | TSHR 1229/4885MAPK1 378/4885CA1 1784/4885 |
| US-20250304599-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE | KRAS, NRAS, HRAS | TSHR 2922/4885MAPK1 670/4885CA1 2977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.