Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552519 | 0.87 | SCN9A (0.42) | SCN9A | |
| SCHEMBL1552517 | 0.87 | SCN9A (0.42) | SCN9A | |
| SCHEMBL1552954 | 0.73 | SLC6A4 (0.38) | HRH1 | |
| SCHEMBL1552952 | 0.73 | SLC6A4 (0.38) | HRH1 | |
| SCHEMBL1552955 | 0.73 | SLC6A4 (0.38) | HRH1 | |
| SCHEMBL4746196 | 0.70 | REN (0.36) | POLBLMNASMN1; SMN2ENPP2PTGDR2 | |
| SCHEMBL23764633 | 0.68 | POLB (0.58) | POLBLMNASMN1; SMN2ENPP2HRH2 | |
| SCHEMBL9212935 | 0.68 | POLB (0.58) | POLBLMNASMN1; SMN2ENPP2HRH2 | |
| SCHEMBL3769071 | 0.68 | POLB (0.58) | POLBLMNASMN1; SMN2ENPP2HRH2 | |
| SCHEMBL28018928 | 0.67 | POLB (0.57) | POLBLMNASMN1; SMN2ENPP2P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844026-B1 | MORPHOLINES AS 5HT2C AGONISTS | HOFFMANN LA ROCHE (CH) | 2011-04-27 | — | — | EP | disclosed |