Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748944 | 0.88 | KAT6A (0.41) | REN | |
| SCHEMBL4746988 | 0.79 | ALDH1A1 (0.34) | RENKDM4ENPC1HPGDRAB9A | |
| SCHEMBL4748799 | 0.78 | MTNR1A (0.35) | RENGRIN2BKDM4ENPC1GLA | |
| SCHEMBL5616691 | 0.75 | REN (0.39) | RENGRIN2BP2RY12LMNAPOLB | |
| SCHEMBL1551996 | 0.70 | POLB (0.36) | GRIN2BP2RY12LMNAPOLBSMN1; SMN2 | |
| SCHEMBL5616690 | 0.70 | REN (0.45) | RENP2RY12LMNAPOLBSMN1; SMN2 | |
| SCHEMBL28018928 | 0.68 | POLB (0.57) | P2RY12LMNAPOLBSMN1; SMN2ENPP2 | |
| SCHEMBL5599014 | 0.68 | REN (0.57) | REN | |
| SCHEMBL5599018 | 0.68 | REN (0.57) | REN | |
| SCHEMBL23764633 | 0.65 | POLB (0.58) | HPGDLMNAPOLBSMN1; SMN2ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124582-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |