Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 5/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474463 | 0.84 | GPR55 (0.39) | CFTR | |
| SCHEMBL12163777 | 0.84 | GPR55 (0.39) | CFTR | |
| SCHEMBL474847 | 0.80 | HSD11B1 (0.34) | SCN9A | |
| SCHEMBL473952 | 0.78 | GPR55 (0.39) | PTGER4 | |
| SCHEMBL12163803 | 0.78 | GPR55 (0.39) | PTGER4 | |
| SCHEMBL474474 | 0.77 | GPR55 (0.37) | RXRARXRBWDR5 | |
| SCHEMBL12163784 | 0.77 | GPR55 (0.37) | RXRARXRBWDR5 | |
| SCHEMBL474284 | 0.76 | ALDH1A1 (0.38) | — | |
| SCHEMBL15520696 | 0.73 | GPR55 (0.37) | — | |
| SCHEMBL473937 | 0.73 | ALDH1A1 (0.35) | PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411365-B1 | 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2014-03-19 | — | — | EP | disclosed |