Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2252922 | 0.77 | KCNN4 (0.35) | MAPK1ALDH1A1CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL9494144 | 0.71 | CYP2D6 (0.41) | MAPK1ALDH1A1CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL18544226 | 0.71 | CYP2D6 (0.41) | MAPK1ALDH1A1CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL18544240 | 0.70 | ALDH1A1 (0.58) | MAPK1ALDH1A1CYP2D6CYP2C19ALOX15 | |
| SCHEMBL6809764 | 0.70 | ALDH1A1 (0.46) | MAPK1ALDH1A1CYP2D6CYP2C19ALOX15 | |
| SCHEMBL3969286 | 0.69 | KIF11 (0.40) | MAPK1ALDH1A1CYP2D6CYP2C19ALOX15 | |
| SCHEMBL11147173 | 0.69 | ALDH1A1 (0.39) | MAPK1ALDH1A1CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL28467487 | 0.69 | CYP2D6 (0.44) | MAPK1ALDH1A1CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL4462032 | 0.67 | ALDH1A1 (0.43) | MAPK1ALDH1A1CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL4459729 | 0.67 | ALDH1A1 (0.35) | MAPK1ALDH1A1CYP2D6CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313422-B1 | NUCLEOSIDE CYCLICPHOSPHATES | GILEAD PHARMASSET LLC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8759510-B2 | Nucleoside cyclicphosphates | GILEAD PHARMASSET LLC (US) | 2014-06-24 | — | — | US | disclosed |
| US-20120258928-A1 | NUCLEOSIDE CYCLICPHOSPHATES | GILEAD PHARMASSET LLC (US) | 2012-10-11 | — | — | US | disclosed |
| US-8173621-B2 | Nucleoside cyclicphosphates | GILEAD PHARMASSET LLC (US) | 2012-05-08 | — | — | US | disclosed |
| EP-2313422-A2 | NUCLEOSIDE CYCLICPHOSPHATES | Pharmasset, Inc. (US) | 2011-04-27 | — | — | EP | disclosed |
| US-20100081628-A1 | NUCLEOSIDE CYCLICPHOSPHATES | PHARMASSET, INC. (US) | 2010-04-01 | — | — | US | disclosed |
| WO-2009152095-A2 | NUCLEOSIDE CYCLICPHOSPHATES | PHARMASSET, INC. (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258928-A1 | NUCLEOSIDE CYCLICPHOSPHATES | PNP, NUDT1, TYMP | MAPK1 2665/4885ALDH1A1 3540/4885CYP2D6 3301/4885 |
| US-20100081628-A1 | NUCLEOSIDE CYCLICPHOSPHATES | PNP, NUDT1, TYMP | MAPK1 2665/4885ALDH1A1 3540/4885CYP2D6 3301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.