SCHEMBL15520262

SCHEMBL15520262

CC(c1ccc(-c2ccccc2OC(=O)O)cc1Cl)C(O)(c1ccc2c(c1)N(C)C(=O)CO2)C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GPR55 Q9Y2T6 1/20 0.36
TSHR P16473 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
KMO O15229 2/20 0.33
ALDH1A1 P00352 1/20 0.33
NR1H2 P55055 2/20 0.33
NR1H3 Q13133 2/20 0.33
RORC P51449 2/20 0.32
THRB P10828 1/20 0.32
PDE3B Q13370 1/20 0.32
PDE3A Q14432 1/20 0.32
L3MBTL1 Q9Y468 2/20 0.31
CTSC P53634 1/20 0.31
CYP3A4 P08684 3/20 0.31
CYP2D6 P10635 3/20 0.31
OPRK1 P41145 3/20 0.31
UTS2R Q9UKP6 3/20 0.31
USP30 Q70CQ3 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15520371 0.91 GPR55 (0.37) GPR55TSHRNPSR1KMOALDH1A1
SCHEMBL15520206 0.90 GPR55 (0.37) GPR55TSHRNPSR1KMOALDH1A1
SCHEMBL15520533 0.89 GPR55 (0.38) GPR55TSHRNPSR1KMOALDH1A1
SCHEMBL15520752 0.89 GPR55 (0.38) GPR55TSHRNPSR1KMOALDH1A1
SCHEMBL15520803 0.89 GPR55 (0.38) GPR55TSHRNPSR1KMOALDH1A1
SCHEMBL15520532 0.89 GPR55 (0.38) GPR55TSHRNPSR1KMOALDH1A1
SCHEMBL474579 0.88 GPR55 (0.35) GPR55ALDH1A1NR1H2NR1H3RORC
SCHEMBL12163813 0.88 GPR55 (0.35) GPR55ALDH1A1NR1H2NR1H3RORC
SCHEMBL15520843 0.88 GPR55 (0.36) GPR55TSHRKMOALDH1A1PDE3B
SCHEMBL15519642 0.88 GPR55 (0.37) GPR55KMOALDH1A1THRBPDE3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2411365-B1 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS HOFFMANN LA ROCHE (CH) 2014-03-19 EP claimed