Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.70 |
| ▸ | TOP1 | P11387 | 11/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239024 | 0.90 | CHRM1 (0.57) | CHRM1MAPTTP53 | |
| SCHEMBL2487847 | 0.89 | CHRM1 (0.70) | CHRM1TOP1 | |
| SCHEMBL2486084 | 0.87 | CHRM1 (0.53) | CHRM1TOP1MAPTTP53 | |
| SCHEMBL3236790 | 0.86 | CHRM1 (0.53) | CHRM1 | |
| SCHEMBL2490524 | 0.85 | CHRM1 (0.71) | CHRM1TOP1SERPINE1TP53 | |
| SCHEMBL2489039 | 0.85 | CHRM1 (0.74) | CHRM1TOP1SERPINE1MAPTTP53 | |
| SCHEMBL3237430 | 0.85 | CHRM1 (0.53) | CHRM1MAPT | |
| SCHEMBL3239724 | 0.84 | CHRM1 (0.50) | CHRM1MAPT | |
| SCHEMBL3241350 | 0.84 | CHRM1 (0.56) | CHRM1SERPINE1 | |
| SCHEMBL2490815 | 0.83 | CHRM1 (0.49) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |