Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.56 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD1 | P21728 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.56 |
| ▸ | DRD5 | P21918 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | APEX1 | P27695 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | THPO | P40225 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrocaffeic Acid SCHEMBL245530 | 0.91 | IAPP (0.65) | KDM4EMAPTTDP1ALOX15RECQL | |
| Dihydrocaffeic Acid SCHEMBL7058919 | 0.91 | IAPP (0.65) | KDM4EMAPTTDP1ALOX15RECQL | |
| Dihydrocaffeic Acid SCHEMBL29351390 | 0.91 | IAPP (0.65) | KDM4EMAPTTDP1ALOX15RECQL | |
| Dihydrocaffeic Acid SCHEMBL175650 | 0.85 | KDM4E (0.55) | KDM4EMAPTTDP1ALOX15RECQL | |
| Dihydrocaffeic Acid SCHEMBL31017610 | 0.84 | IAPP (0.57) | KDM4EMAPTTDP1ALOX15RECQL | |
| Acetic Acid SCHEMBL27634531 | 0.82 | KDM4E (0.58) | KDM4EMAPTTDP1ALOX15RECQL | |
| SCHEMBL110644 | 0.81 | KDM4E (0.67) | KDM4EMAPTTDP1ALOX15RECQL | |
| SCHEMBL29359577 | 0.81 | KDM4E (0.67) | KDM4EMAPTTDP1ALOX15RECQL | |
| SCHEMBL31273986 | 0.80 | KEAP1 (0.61) | MAPK1SLC6A3CYP2D6ADRA1ATSHR | |
| SCHEMBL18788836 | 0.80 | IGF1R (0.67) | KDM4EMAPTTDP1ALOX15HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2527315-B1 | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes and Parkinson's disease | PROTEOTECH INC (US) | 2014-03-19 | — | — | EP | disclosed |