Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903214 | 0.82 | ALDH1A1 (0.52) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL2032093 | 0.81 | SMN1; SMN2 (0.43) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL374759 | 0.81 | ALDH1A1 (0.42) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL312212 | 0.79 | L3MBTL1 (0.37) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL16053330 | 0.79 | ALDH1A1 (0.41) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL2546883 | 0.79 | POLB (0.45) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL17713984 | 0.79 | SMN1; SMN2 (0.42) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL19869979 | 0.79 | LMNA (0.50) | SMN1; SMN2LMNAMAPK1L3MBTL1 | |
| Formaldehyde SCHEMBL27853879 | 0.77 | SMN1; SMN2 (0.41) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL1349979 | 0.74 | ALDH1A1 (0.50) | SMN1; SMN2LMNAHTTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829010-B2 | Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or CYP3A4 inhibitors | PFIZER INC. (US) | 2014-09-09 | — | — | US | disclosed |
| US-20140080806-A1 | PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS PDE2 INHIBITORS AND/OR CYP3A4 INHIBITORS | HELAL CHRISTOPHER JOHN (US) | 2014-03-20 | — | — | US | disclosed |
| CN-103596956-A | Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or cyp3A4 inhibitors | PFIZER | 2014-02-19 | — | — | CN | disclosed |
| CN-102869664-A | Pyrazolopyrimidine kinase inhibitors | VERTEX PHARMA | 2013-01-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080806-A1 | PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS AND THEIR USE AS PDE2 INHIBITORS AND/OR CYP3A4 INHIBITORS | PDE12, PDE2A, CYP1A2 | PDE4A 9/4885PDE4B 7/4885PDE4C 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.