Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.51 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.51 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15525567 | 1.00 | KMT2A (0.58) | KMT2AKDM4ENPC1TP53RAB9A | |
| SCHEMBL16685883 | 0.86 | XDH (0.48) | KMT2AKDM4ENPC1TP53RAB9A | |
| SCHEMBL18983184 | 0.86 | XDH (0.48) | KMT2AKDM4ENPC1TP53RAB9A | |
| SCHEMBL18983206 | 0.84 | P4HB (0.56) | KMT2AKDM4ENPC1TP53RAB9A | |
| SCHEMBL16685923 | 0.84 | P4HB (0.56) | KMT2AKDM4ENPC1TP53RAB9A | |
| SCHEMBL18165781 | 0.84 | NPC1 (0.44) | KMT2AKDM4ENPC1TP53RAB9A | |
| SCHEMBL20112821 | 0.84 | MAPT (0.54) | KMT2ANPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL18153585 | 0.81 | KMT2A (0.53) | KMT2AKDM4ENPC1TP53RAB9A | |
| SCHEMBL16685494 | 0.81 | KMT2A (0.53) | KMT2AKDM4ENPC1TP53RAB9A | |
| SCHEMBL6292983 | 0.80 | BCHE (0.54) | KMT2ANFKB1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043443-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | UNIV CASE WESTERN RESERVE (US) | 2024-02-08 | — | — | US | disclosed |
| US-20210032265-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-02-04 | — | — | US | disclosed |
| US-20200140453-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-05-07 | — | — | US | disclosed |
| US-10301320-B2 | Compositions and methods of modulating 15-PGDH activity | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2019-05-28 | — | — | US | disclosed |
| CN-108546254-A | 5- (3- phenyl acryloyls) thiazole and the preparation method and application thereof | 湖南大学 | 2018-09-18 | — | — | CN | disclosed |
| CN-108546254-A | 5- (3- phenyl acryloyls) thiazole and the preparation method and application thereof | 湖南大学 | 2018-09-18 | — | — | CN | disclosed |
| EP-3295940-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | Case Western Reserve University (US) | 2018-03-21 | — | — | EP | disclosed |
| US-9790233-B2 | Compositions and methods of modulating 15-PGDH activity | CASE WESTERN RESERVE UNIVERSITY (US) | 2017-10-17 | — | — | US | disclosed |
| EP-2838533-B1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | UNIV CASE WESTERN RESERVE (US) | 2017-10-04 | — | — | EP | disclosed |
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-15 | — | — | US | disclosed |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2015-03-12 | — | — | US | disclosed |
| EP-2838533-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | Case Western Reserve University (US) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013158649-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2013-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | KMT2A 4177/4885KDM4E 3434/4885NPC1 1675/4885 |
| US-20200140453-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | KMT2A 4177/4885KDM4E 3434/4885NPC1 1675/4885 |
| US-20240043443-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | KMT2A 4177/4885KDM4E 3434/4885NPC1 1675/4885 |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | KMT2A 4177/4885KDM4E 3434/4885NPC1 1675/4885 |
| US-20210032265-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | KMT2A 4177/4885KDM4E 3434/4885NPC1 1675/4885 |
| US-10301320-B2 | Compositions and methods of modulating 15-PGDH activity | PTGS1, HPGD, PTGIS | KMT2A 4177/4885KDM4E 3434/4885NPC1 1675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.