Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 5/20 | 0.31 |
| ▸ | NPC1 | O15118 | 4/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474122 | 0.81 | KDM4E (0.44) | NNMTMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL29551416 | 0.81 | KDM4E (0.44) | NNMTMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL384113 | 0.79 | NNMT (0.61) | NNMTSIRT6MKNK1MKNK2KMT2A | |
| SCHEMBL29799541 | 0.79 | NNMT (0.61) | NNMTSIRT6MKNK1MKNK2KMT2A | |
| SCHEMBL16333365 | 0.78 | NNMT (0.42) | NNMTSIRT6NAPRTMAPTHAVCR2 | |
| SCHEMBL28662886 | 0.78 | NNMT (0.42) | NNMTCYP2C9SIRT6NAPRTMAPT | |
| SCHEMBL29577063 | 0.78 | NNMT (0.42) | NNMTSIRT6NAPRTMAPTHAVCR2 | |
| SCHEMBL18298896 | 0.77 | ATR (0.43) | NNMTCYP2C9KCNH2NLRP3NFKB1 | |
| SCHEMBL22834911 | 0.77 | CA12 (0.42) | NNMTCYP2C9MAPTRAB9ANPC1 | |
| SCHEMBL31280472 | 0.77 | NNMT (0.41) | NNMTCYP2C9KCNH2NLRP3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013186612-A1 | THE USE OF SUBSTITUTED 2-PHENYL-3H-QUINAZOLIN-4-ONES AND ANALOGS FOR INHIBITING BET (BROMODOMAIN AND EXTRA TERMINAL DOMAIN) PROTEINS | RVX THERAPEUTICS INC. (CA) | 2013-12-19 | — | — | WO | disclosed |
| WO-2013156869-A1 | TREATMENT OF DISEASES BY EPIGENETIC REGULATION | RVX THERAPEUTICS INC. (CA) | 2013-10-24 | — | — | WO | disclosed |