Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 5/20 | 0.61 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29799541 | 1.00 | NNMT (0.61) | NNMTSIRT6CA12CA1CA2 | |
| Methoxymethane SCHEMBL27172554 | 0.93 | NNMT (0.58) | NNMTSIRT6CA12CA1CA2 | |
| SCHEMBL29577063 | 0.83 | NNMT (0.42) | NNMTSIRT6KMT2A | |
| SCHEMBL16333365 | 0.83 | NNMT (0.42) | NNMTSIRT6KMT2A | |
| SCHEMBL28662886 | 0.83 | NNMT (0.42) | NNMTSIRT6KMT2ALMNA | |
| SCHEMBL17362420 | 0.82 | SIRT6 (0.47) | NNMTSIRT6MKNK1MKNK2LMNA | |
| SCHEMBL625580 | 0.81 | SMN1; SMN2 (0.47) | NNMTSIRT6CA12CA1CA2 | |
| SCHEMBL29446081 | 0.81 | SMN1; SMN2 (0.47) | NNMTSIRT6CA12CA1CA2 | |
| SCHEMBL5878762 | 0.80 | NNMT (0.62) | NNMTCA12CA1CA2CA3 | |
| SCHEMBL22291660 | 0.80 | NNMT (0.59) | NNMTSIRT6MKNK1MKNK2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 234 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743068-B1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | EXELIXIS INC (US) | 2026-04-29 | — | — | EP | disclosed |
| US-20260001898-A1 | Heteroaryl compounds as inhibitors of TYK2/JAK1, composition and application thereof | ACCRO BIOSCIENCE HK LTD (HK) | 2026-01-01 | — | — | US | disclosed |
| US-20250270190-A1 | KIT INHIBITORS | BLUEPRINT MEDICINES CORPORATION | 2025-08-28 | — | — | US | disclosed |
| EP-4551559-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF TYK2/JAK1, COMPOSITION AND APPLICATION THEREOF | Accro Bioscience (HK) Limited (HK) | 2025-05-14 | — | — | EP | disclosed |
| US-12240840-B2 | Amide-substituted heterocyclic compounds for the treatment of conditions related to the modulation of IL-12, IL-23 and/or IFN-alpha | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-03-04 | — | — | US | disclosed |
| US-12195475-B2 | Compounds for the treatment of kinase-dependent disorders | EXELIXIS, INC. (US) | 2025-01-14 | — | — | US | disclosed |
| US-20250011335-A1 | SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, AND 1,2,4-TRIAZINES AS TYK2 INHIBITORS | SUDO BIOSCIENCES LIMITED (GB) | 2025-01-09 | — | — | US | disclosed |
| US-20240425456-A1 | DEGRADER | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2024-12-26 | — | — | US | disclosed |
| WO-2024253416-A1 | PYRIMIDINE/PYRIDINE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | YUHAN CORPORATION (KR) | 2024-12-12 | — | — | WO | disclosed |
| US-20240391934-A1 | SUBSTITUTED PYRIDINES AND PYRIDAZINES AS TYK2 INHIBITORS | SUDO BIOSCIENCES LTD (GB) | 2024-11-28 | — | — | US | disclosed |
| WO-2009111676-A2 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC (US) | 2009-09-11 | — | — | WO | disclosed |
| WO-2009111676-A2 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC (US) | 2009-09-11 | — | — | WO | disclosed |
| EP-1866286-B1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-05-27 | — | — | EP | disclosed |
| EP-1866286-B1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-05-27 | — | — | EP | disclosed |
| US-7468382-B2 | Pyridine derivatives useful as inhibitors of PKC-theta | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-23 | — | — | US | disclosed |
| US-7468382-B2 | Pyridine derivatives useful as inhibitors of PKC-theta | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-23 | — | — | US | disclosed |
| US-7468382-B2 | Pyridine derivatives useful as inhibitors of PKC-theta | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-23 | — | — | US | disclosed |
| EP-1866286-A1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105023-A1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-10-05 | — | — | WO | disclosed |
| US-20060217417-A1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250011335-A1 | SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, AND 1,2,4-TRIAZINES AS TYK2 INHIBITORS | TYK2, PDXK, JAK1 | NNMT 838/4885SIRT6 1301/4885CA12 4846/4885 |
| US-20240425456-A1 | DEGRADER | JAK3, JAK1, JAK2 | NNMT 3109/4885SIRT6 2808/4885CA12 4106/4885 |
| US-20240391934-A1 | SUBSTITUTED PYRIDINES AND PYRIDAZINES AS TYK2 INHIBITORS | TYK2, PDXK, TPX2 | NNMT 1494/4885SIRT6 1124/4885CA12 4778/4885 |
| US-20250270190-A1 | KIT INHIBITORS | KIT, ABL1, APC | NNMT 2419/4885SIRT6 3128/4885CA12 3166/4885 |
| US-12195475-B2 | Compounds for the treatment of kinase-dependent disorders | ERBB2, ERBB3, MAP3K6 | NNMT 507/4885SIRT6 1919/4885CA12 3858/4885 |
| US-20260001898-A1 | Heteroaryl compounds as inhibitors of TYK2/JAK1, composition and application thereof | JAK1, JAK2, TYK2 | NNMT 2150/4885SIRT6 1490/4885CA12 3342/4885 |
| US-20060217417-A1 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | PRKCQ, PRKCH, PRKCZ | NNMT 1646/4885SIRT6 2353/4885CA12 4055/4885 |
| US-12240840-B2 | Amide-substituted heterocyclic compounds for the treatment of conditions related to the modulation of IL-12, IL-23 and/or IFN-alpha | TYK2, IFNG, JAK3 | NNMT 2555/4885SIRT6 944/4885CA12 2820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.