Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SCN4A | P35499 | 2/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3702329 | 0.88 | TSHR (0.46) | KMT2ASMN1; SMN2SCN4ACFDTPSB2 | |
| SCHEMBL3967907 | 0.82 | TSHR (0.52) | KMT2ASMN1; SMN2TSHRMAPK1HIF1A | |
| SCHEMBL20483108 | 0.82 | MAPK1 (0.43) | KMT2ASMN1; SMN2TSHRMAPK1HIF1A | |
| SCHEMBL4568763 | 0.80 | MAPK1 (0.50) | KMT2ASMN1; SMN2TSHRMAPK1HIF1A | |
| SCHEMBL4568972 | 0.80 | MAPK1 (0.50) | KMT2ASMN1; SMN2TSHRMAPK1HIF1A | |
| SCHEMBL4568971 | 0.80 | MAPK1 (0.50) | KMT2ASMN1; SMN2TSHRMAPK1HIF1A | |
| SCHEMBL3967162 | 0.80 | ALDH1A1 (0.47) | KMT2ASMN1; SMN2SCN4ACFDTPSB2 | |
| SCHEMBL3972726 | 0.80 | SCN4A (0.47) | KMT2ASMN1; SMN2SCN4ACFDTPSB2 | |
| SCHEMBL20332600 | 0.79 | HIF1A (0.39) | KMT2ASMN1; SMN2TSHRMAPK1HIF1A | |
| SCHEMBL3972169 | 0.79 | SMN1; SMN2 (0.45) | KMT2ASMN1; SMN2CFDTPSB2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844636-A2 | METHODS FOR THE TREATMENT OF DIABETIC RETINOPATHY AND OTHER OPHTHALMIC DISEASES | Acucela, Inc. (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013166449-A2 | METHODS FOR THE TREATMENT OF DIABETIC RETINOPATHY AND OTHER OPHTHALMIC DISEASES | ACUCELA INC. (US) | 2013-11-07 | — | — | WO | disclosed |