Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964690 | 0.89 | CYP1A2 (0.43) | TSHRCYSLTR2CYSLTR1MAPK1CYP1A2 | |
| SCHEMBL3972169 | 0.88 | SMN1; SMN2 (0.45) | TSHRALDH1A1LMNARECQLKMT2A | |
| SCHEMBL3967162 | 0.87 | ALDH1A1 (0.47) | TSHRALDH1A1LMNARECQLKMT2A | |
| SCHEMBL3968473 | 0.86 | MAPK1 (0.43) | TSHRALOX5SLC2A1MAPK1CYP1A2 | |
| SCHEMBL3706818 | 0.85 | TSHR (0.39) | TSHRCYSLTR2CYSLTR1ALOX5MAPK1 | |
| SCHEMBL3966429 | 0.84 | TDP1 (0.44) | TSHRMAPK1MEN1ALDH1A1LMNA | |
| SCHEMBL3972478 | 0.84 | CHEK2 (0.42) | TSHRMAPK1CYP1A2CYP2C19MEN1 | |
| SCHEMBL11663942 | 0.84 | TSHR (0.56) | TSHRCYSLTR2CYSLTR1ALOX5SLC2A1 | |
| SCHEMBL15526464 | 0.82 | KMT2A (0.43) | TSHRMAPK1HIF1AKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8502991 | 0.81 | TSHR (0.48) | TSHRCYSLTR2CYSLTR1ALOX5SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |