Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CFD | P00746 | 1/20 | 0.46 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | SCN4A | P35499 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972169 | 0.92 | SMN1; SMN2 (0.45) | ALDH1A1RECQLCFDTPSB2SMN1; SMN2 | |
| SCHEMBL3972478 | 0.88 | CHEK2 (0.42) | ALDH1A1CFDTPSB2SMN1; SMN2KMT2A | |
| SCHEMBL3966429 | 0.88 | TDP1 (0.44) | ALDH1A1CFDTPSB2SMN1; SMN2KMT2A | |
| SCHEMBL3967907 | 0.87 | TSHR (0.52) | ALDH1A1RECQLSMN1; SMN2KMT2ATSHR | |
| SCHEMBL3968473 | 0.87 | MAPK1 (0.43) | ALDH1A1CFDTPSB2SMN1; SMN2KMT2A | |
| SCHEMBL3964690 | 0.87 | CYP1A2 (0.43) | ALDH1A1CFDTPSB2SMN1; SMN2KMT2A | |
| SCHEMBL10513076 | 0.86 | ALDH1A1 (0.46) | ALDH1A1RECQLSMN1; SMN2KMT2AKDM4E | |
| SCHEMBL3966532 | 0.86 | KMT2A (0.52) | CFDTPSB2SMN1; SMN2KMT2A | |
| SCHEMBL8723946 | 0.85 | ALDH1A1 (0.52) | ALDH1A1RECQLSMN1; SMN2KMT2AKDM4E | |
| SCHEMBL3706818 | 0.83 | TSHR (0.39) | ALDH1A1CFDTPSB2SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |