Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | NNMT | P40261 | 2/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945799 | 0.80 | MKNK1 (0.71) | MKNK1MKNK2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL7229408 | 0.78 | MKNK1 (0.52) | MKNK1MKNK2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL18755203 | 0.77 | CYP2A6 (0.50) | MKNK1MKNK2CYP2A6NNMTHSD17B1 | |
| SCHEMBL7224515 | 0.77 | MKNK1 (0.55) | MKNK1MKNK2CYP2A6NNMTRCE1 | |
| SCHEMBL65277 | 0.76 | NNMT (0.68) | MKNK1MKNK2KDM4EALDH1A1NNMT | |
| SCHEMBL15526455 | 0.75 | GABRA5 (0.40) | KDM4EALDH1A1CYP2A6MEN1KMT2A | |
| SCHEMBL16056270 | 0.74 | KDM4E (0.53) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL10832764 | 0.74 | CA1 (0.58) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL18755011 | 0.71 | CYP2A6 (0.44) | MKNK1MKNK2CYP2A6NNMTHSD17B1 | |
| SCHEMBL3101392 | 0.71 | HDAC6 (0.52) | MKNK1MKNK2KDM4EALDH1A1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844252-B1 | CYCLIC AMINE SUBSTITUTED HETEROCYCLIC COMPOUNDS AS CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2016-11-30 | — | — | EP | disclosed |
| US-9353101-B2 | Cyclic amine substituted heterocyclic CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20150111866-A1 | CYCLIC AMINE SUBSTITUTED HETEROCYCLIC CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-23 | — | — | US | disclosed |
| EP-2844252-A1 | CYCLIC AMINE SUBSTITUTED HETEROCYCLIC CETP INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013165854-A1 | CYCLIC AMINE SUBSTITUTED HETEROCYCLIC CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111866-A1 | CYCLIC AMINE SUBSTITUTED HETEROCYCLIC CETP INHIBITORS | CETP, APOB, MTTP | MKNK1 3801/4885MKNK2 3926/4885KDM4E 1726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.