SCHEMBL15526593

SCHEMBL15526593

CC(C)[Si](C(C)C)(n1ccnc1)[Si](C(C)C)(C(C)C)n1ccnc1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 1/20 0.40
QPCT Q16769 1/20 0.40
HSD17B10 Q99714 1/20 0.40
QPCTL Q9NXS2 1/20 0.40
HTT P42858 1/20 0.34
CYP19A1 P11511 1/20 0.32
CYP17A1 P05093 3/20 0.32
CYP26A1 O43174 1/20 0.30
TBXAS1 P24557 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27003116 0.80 QPCT (0.40) NFKB1QPCTHSD17B10QPCTLHTT
SCHEMBL918948 0.78 NFKB1 (0.39) NFKB1QPCTHSD17B10QPCTLCYP19A1
SCHEMBL10503985 0.70 NFKB1 (0.46) NFKB1QPCTHSD17B10QPCTLHTT
SCHEMBL217284 0.70
SCHEMBL12020402 0.69 NFKB1 (0.43) NFKB1QPCTHSD17B10QPCTLHTT
Bromide SCHEMBL28508208 0.69 NFKB1 (0.43) NFKB1QPCTHSD17B10QPCTLHTT
SCHEMBL23302369 0.65 NFKB1 (0.40) NFKB1QPCTHSD17B10QPCTLHTT
SCHEMBL1953406 0.65 NFKB1 (0.40) NFKB1QPCTHSD17B10QPCTLHTT
SCHEMBL538362 0.65 NFKB1 (0.40) NFKB1QPCTHSD17B10QPCTLHTT
SCHEMBL40476 0.63 NFKB1 (0.39) NFKB1QPCTHSD17B10QPCTLCYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2841401-B1 METHOD FOR PROTECTING HYDROXYL, AMINE OR THIOL FUNCTIONAL GROUPS WITH TETRAISOPROPYLDISILANE AND THE CORRESPONDING PROTECTED COMPOUNDS INST CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK (PL) 2018-07-04 EP disclosed
US-9290521-B2 Method for protecting hydroxyl or amine or thiol functions, novel compounds with protected hydroxyl or amine or thiol groups, as well novel compounds for the implementation of this method INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK (PL) 2016-03-22 US disclosed
US-20150094462-A1 METHOD FOR PROTECTING HYDROXYL OR AMINE OR THIOL FUNCTIONS, NOVEL COMPOUNDS WITH PROTECTED HYDROXYL OR AMINE OR THIOL GROUPS, AS WELL NOVEL COMPOUNDS FOR THE IMPLEMENTATION OF THIS METHOD FUNDACJA UNIWERSYTETU IM. ADAMA MICKIEWICZA W POZNANIU (PL) 2015-04-02 US disclosed
EP-2841401-A1 METHOD FOR PROTECTING HYDROXYL, AMINE OR THIOL FUNCTIONAL GROUPS WITH TETRAISOPROPYDISILANE AND THE CORRESPONDING PROTECTED COMPOUNDS Instytut Chemii Bioorganicznej Polskiej Akademii Nauk (PL) 2015-03-04 EP disclosed
WO-2013165266-A1 METHOD FOR PROTECTING HYDROXYL, AMINE OR THIOL FUNCTIONAL GROUPS WITH TETRAISOPROPYDISILANE AND THE CORRESPONDING PROTECTED COMPOUNDS INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK (PL) 2013-11-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150094462-A1 METHOD FOR PROTECTING HYDROXYL OR AMINE OR THIOL FUNCTIONS, NOVEL COMPOUNDS WITH PROTECTED HYDROXYL OR AMINE OR THIOL GROUPS, AS WELL NOVEL COMPOUNDS FOR THE IMPLEMENTATION OF THIS METHOD DUS2, TXN, OGG1 NFKB1 3704/4885QPCT 1044/4885HSD17B10 1635/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.