Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 12/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 12/20 | 0.46 |
| ▸ | PARP1 | P09874 | 6/20 | 0.46 |
| ▸ | SPR | P35270 | 7/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL15527835 | 0.94 | TNKS (0.45) | TNKSTNKS2PARP1SPR | |
| SCHEMBL15527718 | 0.89 | TNKS (0.49) | TNKSTNKS2PARP1SPR | |
| SCHEMBL15527466 | 0.87 | TNKS (0.62) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL15527713 | 0.82 | TNKS (0.46) | TNKSTNKS2PARP1SPR | |
| SCHEMBL15528007 | 0.81 | TNKS (0.46) | TNKSTNKS2PARP1SPR | |
| SCHEMBL15527797 | 0.81 | TNKS (0.41) | TNKSTNKS2PARP1SPR | |
| SCHEMBL15527819 | 0.80 | SPR (0.46) | TNKSTNKS2PARP1SPR | |
| SCHEMBL15527580 | 0.79 | TNKS2 (0.46) | TNKSTNKS2PARP1SPRWNT3A | |
| SCHEMBL15527773 | 0.79 | TNKS (0.52) | TNKSTNKS2PARP1SPR | |
| SCHEMBL16699512 | 0.76 | SPR (0.49) | SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844659-B1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-05-25 | — | — | EP | claimed |
| US-9174995-B2 | Pyrrolotriazinone derivatives | MERCK PATENT GMBH (DE) | 2015-11-03 | — | — | US | claimed |
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | claimed |
| EP-2844659-A1 | PYRROLOTRIAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2015-03-11 | — | — | EP | claimed |
| WO-2013164061-A1 | PYRROLOTRIAZINONE DERIVATIVES | dedeMERCK PATENT GMBH (DE) | 2013-11-07 | — | — | WO | claimed |
| EP-2844659-B1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-05-25 | — | — | EP | disclosed |
| EP-2844659-B1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-05-25 | — | — | EP | disclosed |
| US-9174995-B2 | Pyrrolotriazinone derivatives | MERCK PATENT GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-9174995-B2 | Pyrrolotriazinone derivatives | MERCK PATENT GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-9174995-B2 | Pyrrolotriazinone derivatives | MERCK PATENT GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | disclosed |
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | disclosed |
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | disclosed |
| EP-2844659-A1 | PYRROLOTRIAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013164061-A1 | PYRROLOTRIAZINONE DERIVATIVES | dedeMERCK PATENT GMBH (DE) | 2013-11-07 | — | — | WO | disclosed |
| WO-2013164061-A1 | PYRROLOTRIAZINONE DERIVATIVES | dedeMERCK PATENT GMBH (DE) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | TNKS, TBKBP1, TNKS1BP1 | TNKS 1/4885TNKS2 8/4885PARP1 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.