Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15527819 | 0.85 | SPR (0.46) | SPRKMT2AALDH1A1HPGDRNASEH1 | |
| SCHEMBL15527577 | 0.84 | TNKS (0.53) | SPRKDM4EALDH1A1HPGDERCC1 | |
| SCHEMBL15527713 | 0.81 | TNKS (0.46) | SPRADORA1 | |
| SCHEMBL15527580 | 0.81 | TNKS2 (0.46) | SPR | |
| SCHEMBL15527466 | 0.78 | TNKS (0.62) | — | |
| SCHEMBL15527718 | 0.78 | TNKS (0.49) | SPRKDM4EKMT2AALDH1A1 | |
| SCHEMBL15527656 | 0.76 | TNKS (0.46) | SPR | |
| SCHEMBL15527794 | 0.76 | AURKA (0.42) | SPRKDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL15527440 | 0.76 | SPR (0.41) | SPR | |
| SCHEMBL15528007 | 0.76 | TNKS (0.46) | SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174995-B2 | Pyrrolotriazinone derivatives | MERCK PATENT GMBH (DE) | 2015-11-03 | — | — | US | claimed |
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-05-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133453-A1 | PYRROLOTRIAZINONE DERIVATIVES | TNKS, TBKBP1, TNKS1BP1 | SPR 2112/4885KDM4E 706/4885KMT2A 1679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.