Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3514631 | 0.79 | ALDH1A1 (0.41) | ALDH1A1TSHRPKMOPRM1OPRD1 | |
| SCHEMBL15528344 | 0.79 | ALDH1A1 (0.41) | ALDH1A1TSHRPKMALOX15MAPK14 | |
| SCHEMBL9284377 | 0.77 | ALDH1A1 (0.58) | ALDH1A1TSHRPKMOPRM1OPRD1 | |
| SCHEMBL3515379 | 0.76 | KDM4E (0.45) | ALDH1A1TSHROPRM1OPRD1ALOX15 | |
| SCHEMBL3517696 | 0.75 | ALDH1A1 (0.40) | ALDH1A1TSHROPRM1OPRD1ALOX15 | |
| SCHEMBL3515995 | 0.74 | ALDH1A1 (0.44) | ALDH1A1TSHRALOX15KDM4EMEN1 | |
| SCHEMBL3515597 | 0.74 | ALDH1A1 (0.42) | ALDH1A1TSHREGLN1KDM4EMEN1 | |
| SCHEMBL16236741 | 0.73 | CNR1 (0.45) | ALDH1A1PKMEGLN1KDM4EMEN1 | |
| SCHEMBL4299856 | 0.72 | ALDH1A1 (0.46) | ALDH1A1TSHROPRM1OPRD1ALOX15 | |
| SCHEMBL3515840 | 0.72 | SMN1; SMN2 (0.40) | ALDH1A1TSHROPRM1OPRD1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150094327-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2015-04-02 | — | — | US | disclosed |
| WO-2013165898-A2 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094327-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | FEN1, RCE1, APEX1 | ALDH1A1 4188/4885TSHR 4689/4885CYP3A4 2905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.