Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16275027 | 0.84 | CYP1A2 (0.39) | PTK6ALDH1A1TSHRCTSVCTSL | |
| SCHEMBL3516169 | 0.83 | BRD4 (0.48) | SMN1; SMN2ALDH1A1TSHRPPIAMEN1 | |
| SCHEMBL3515379 | 0.81 | KDM4E (0.45) | SMN1; SMN2ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL3514631 | 0.81 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL3517696 | 0.80 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL3515597 | 0.79 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL16274597 | 0.76 | TSHR (0.38) | PTK6ALDH1A1TSHRCTSVCTSL | |
| SCHEMBL3518140 | 0.76 | FEN1 (0.44) | ALDH1A1TSHRKDM4EAURKAMEN1 | |
| SCHEMBL3515445 | 0.76 | OPRM1 (0.35) | SMN1; SMN2ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL3519104 | 0.75 | ALDH1A1 (0.39) | ALDH1A1TSHRL3MBTL1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | SMN1; SMN2 1566/4885PTK6 3665/4885ALDH1A1 1486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.