Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15528124 | 0.79 | ALDH1A1 (0.44) | ALDH1A1TSHRCYP1A2CLK4PKM | |
| SCHEMBL28563529 | 0.72 | PDGFRB (0.40) | ALDH1A1TSHRHDAC8CLK4MKNK2 | |
| SCHEMBL13435221 | 0.72 | ALDH1A1 (0.39) | ALDH1A1TSHRHDAC8CYP1A2MAPK14 | |
| SCHEMBL3517053 | 0.71 | MAPK8 (0.39) | ALDH1A1TSHRCYP1A2MKNK1MKNK2 | |
| SCHEMBL9284377 | 0.70 | ALDH1A1 (0.58) | ALDH1A1TSHRCYP1A2PKMMAPK14 | |
| SCHEMBL16236218 | 0.69 | CNR2 (0.42) | ALDH1A1PKM | |
| SCHEMBL18989228 | 0.68 | CDK4 (0.50) | CDK4CCND1CCND2CCND3 | |
| SCHEMBL15712213 | 0.67 | FGFR1 (0.50) | HDAC8CLK4ENPP3ENPP1MKNK1 | |
| SCHEMBL5370422 | 0.67 | GLO1 (0.42) | HDAC8ENPP3ENPP1GCKMAOB | |
| SCHEMBL20564410 | 0.66 | HDAC3 (0.41) | ALDH1A1TSHRCYP1A2KDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150094327-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2015-04-02 | — | — | US | disclosed |
| WO-2013165898-A2 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094327-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | FEN1, RCE1, APEX1 | ALDH1A1 4188/4885TSHR 4689/4885HDAC8 3283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.