Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15528220 | 0.86 | KDM4E (0.41) | ALDH1A1KDM4ERECQLTGFBR1LMNA | |
| SCHEMBL3517668 | 0.83 | KDM4E (0.48) | ALDH1A1KDM4ERECQLTP53HPGD | |
| SCHEMBL16594575 | 0.83 | ALDH1A1 (0.39) | ALDH1A1KDM4ERECQLTGFBR1LMNA | |
| SCHEMBL3519481 | 0.82 | KDM4E (0.51) | ALDH1A1KDM4ERECQLLMNASMN1; SMN2 | |
| SCHEMBL3519310 | 0.82 | KDM4E (0.44) | ALDH1A1KDM4ERECQLLMNACA12 | |
| SCHEMBL3518359 | 0.82 | KDM4E (0.48) | ALDH1A1KDM4ERECQLLMNASMN1; SMN2 | |
| SCHEMBL3516004 | 0.81 | ALOX5 (0.48) | ALDH1A1KDM4ERECQLLMNA | |
| SCHEMBL3517888 | 0.79 | ALDH1A1 (0.42) | ALDH1A1KDM4ERECQLLMNASMN1; SMN2 | |
| SCHEMBL3514731 | 0.79 | KDM5A (0.43) | ALDH1A1KDM4ERECQLLMNASMN1; SMN2 | |
| SCHEMBL3516008 | 0.78 | EGLN1 (0.42) | ALDH1A1KDM4ERECQLSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150094327-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2015-04-02 | — | — | US | disclosed |
| US-20150093356-A1 | THROMBOPOIETIN MIMETICS | GLAXOSMITHKLINE LLC | 2015-04-02 | — | — | US | disclosed |
| US-20150094327-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2015-04-02 | — | — | US | disclosed |
| US-20150094327-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2015-04-02 | — | — | US | disclosed |
| WO-2013165898-A2 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-11-07 | — | — | WO | disclosed |
| WO-2013165898-A2 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150093356-A1 | THROMBOPOIETIN MIMETICS | MPL, THPO, TEK | ALDH1A1 1012/4885KDM4E 3202/4885RECQL 3970/4885 |
| US-20150094327-A1 | COMPOSITIONS AND METHODS FOR INHIBITING RESOLVASES | FEN1, RCE1, APEX1 | ALDH1A1 4188/4885KDM4E 1800/4885RECQL 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.