Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14306396 | 0.90 | ALOX5 (0.46) | ALOX5PTGESALDH1A1TSHR | |
| SCHEMBL3517735 | 0.86 | ALOX5 (0.45) | ALOX5PTGESKDM4EALDH1A1RECQL | |
| SCHEMBL3519481 | 0.86 | KDM4E (0.51) | KDM4EALDH1A1RECQLTSHRLMNA | |
| SCHEMBL3518359 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1RECQLTSHRLMNA | |
| SCHEMBL3517668 | 0.83 | KDM4E (0.48) | ALOX5PTGESKDM4EALDH1A1RECQL | |
| SCHEMBL3517897 | 0.81 | ALOX5 (0.41) | ALOX5PTGES | |
| SCHEMBL3519310 | 0.81 | KDM4E (0.44) | ALOX5KDM4EALDH1A1RECQLLMNA | |
| SCHEMBL15528328 | 0.81 | ALDH1A1 (0.41) | KDM4EALDH1A1RECQLLMNA | |
| SCHEMBL3517888 | 0.81 | ALDH1A1 (0.42) | ALOX5PTGESKDM4EALDH1A1RECQL | |
| SCHEMBL3514731 | 0.80 | KDM5A (0.43) | KDM4EALDH1A1RECQLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | ALOX5 3513/4885PTGES 4180/4885KDM4E 2380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.