Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15528795 | 0.79 | MAPT (0.36) | MAPTPOLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL28036935 | 0.78 | ALDH1A1 (0.40) | MAPTPOLBRAB9ACHRNB2CHRNA4 | |
| SCHEMBL16660112 | 0.76 | MAPT (0.38) | MAPTPOLBRAB9ACHRNB2CHRNA4 | |
| SCHEMBL1099100 | 0.74 | RAB9A (0.45) | MAPTPOLBRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL28171537 | 0.74 | ALDH1A1 (0.53) | MAPTPOLBMEN1ALDH1A1CRHBP | |
| SCHEMBL27706995 | 0.73 | FDFT1 (0.33) | ALDH1A1 | |
| SCHEMBL8827763 | 0.70 | P4HTM (0.53) | MAPTALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL27961410 | 0.70 | AR (0.37) | MEN1KMT2A | |
| SCHEMBL4551195 | 0.70 | SMN1; SMN2 (0.41) | MAPTRAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL2641830 | 0.70 | BACE1 (0.40) | MAPTRAB9ASMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844656-A1 | SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS | Lupin Limited (IN) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013164773-A1 | SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS | LUPIN LIMITED (IN) | 2013-11-07 | — | — | WO | disclosed |