Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15528877 | 0.87 | TDP1 (0.80) | TDP1THRBTP53GAAALDH1A1 | |
| SCHEMBL4206372 | 0.80 | PKM (0.85) | ALDH1A1MAPTPKMHTTRAB9A | |
| SCHEMBL4204258 | 0.77 | MAPK1 (0.79) | TDP1THRBTP53GAAALDH1A1 | |
| SCHEMBL3903365 | 0.77 | GAA (0.76) | TDP1THRBTP53GAAALDH1A1 | |
| SCHEMBL4207394 | 0.76 | MAPK1 (0.64) | TDP1THRBTP53GAAALDH1A1 | |
| SCHEMBL4208108 | 0.74 | GAA (0.79) | TDP1THRBTP53GAAMAPT | |
| SCHEMBL4202666 | 0.74 | GAA (0.86) | TDP1GAAALDH1A1MAPK1NPSR1 | |
| SCHEMBL18559112 | 0.73 | RECQL (0.81) | TDP1THRBTP53GAAALDH1A1 | |
| SCHEMBL4216623 | 0.72 | ALDH1A1 (0.72) | TDP1ALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL25132313 | 0.71 | GAA (0.70) | GAAALDH1A1MAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2850068-A1 | GPR17 RECEPTOR MODULATORS. | Universita' degli Studi di Milano (IT) | 2015-03-25 | — | — | EP | disclosed |
| WO-2013167177-A1 | GPR17 RECEPTOR MODULATORS. | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2013-11-14 | — | — | WO | disclosed |