Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.80 |
| ▸ | GAA | P10253 | 3/20 | 0.72 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | RGS12 | O14924 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3903365 | 0.89 | GAA (0.76) | TDP1GAATP53THRBSMN1; SMN2 | |
| SCHEMBL15528720 | 0.87 | TDP1 (0.63) | TDP1GAATP53THRBSMN1; SMN2 | |
| SCHEMBL4208108 | 0.86 | GAA (0.79) | TDP1GAATP53THRBSMN1; SMN2 | |
| SCHEMBL4204258 | 0.81 | MAPK1 (0.79) | TDP1GAATP53THRBSMN1; SMN2 | |
| SCHEMBL18559112 | 0.81 | RECQL (0.81) | TDP1GAATP53THRBRAB9A | |
| SCHEMBL4207394 | 0.80 | MAPK1 (0.64) | TDP1GAATP53THRBSMN1; SMN2 | |
| SCHEMBL15986354 | 0.79 | LMNA (0.92) | TDP1GAATP53SMN1; SMN2RAB9A | |
| SCHEMBL30365924 | 0.77 | TP53 (0.77) | TDP1GAATP53THRBSMN1; SMN2 | |
| SCHEMBL4206372 | 0.77 | PKM (0.85) | RAB9AKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL23241877 | 0.76 | MAPT (0.67) | GAATP53THRBMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2850068-B1 | N-(phenyl)-2-[[3-(phenyl)-1H-1,2,4-triazol-5-yl]thio]-acetamide derivatives and related compounds as G protein coupled receptor 17 (GPCR17) modulators for use in the treatment of neuro-degenerative diseases | UNIV DEGLI STUDI MILANO (IT) | 2019-05-29 | — | — | EP | claimed |
| US-9879030-B2 | GPR17 receptor modulators | UNIVERSITA′ DEGLI STUDI DI MILANO (IT) | 2018-01-30 | — | — | US | claimed |
| US-20150141410-A1 | GPR17 Receptor Modulators | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2015-05-21 | — | — | US | claimed |
| EP-2850068-B1 | N-(phenyl)-2-[[3-(phenyl)-1H-1,2,4-triazol-5-yl]thio]-acetamide derivatives and related compounds as G protein coupled receptor 17 (GPCR17) modulators for use in the treatment of neuro-degenerative diseases | UNIV DEGLI STUDI MILANO (IT) | 2019-05-29 | — | — | EP | disclosed |
| US-9879030-B2 | GPR17 receptor modulators | UNIVERSITA′ DEGLI STUDI DI MILANO (IT) | 2018-01-30 | — | — | US | disclosed |
| US-20150141410-A1 | GPR17 Receptor Modulators | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2015-05-21 | — | — | US | disclosed |
| EP-2850068-A1 | GPR17 RECEPTOR MODULATORS. | Universita' degli Studi di Milano (IT) | 2015-03-25 | — | — | EP | disclosed |
| WO-2013167177-A1 | GPR17 RECEPTOR MODULATORS. | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2013-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141410-A1 | GPR17 Receptor Modulators | GPR65, GPR27, GPR17 | TDP1 4116/4885GAA 2188/4885TP53 4565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.