Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29119862 | 0.86 | PRMT1 (0.49) | MEN1KMT2APRMT1CYP2C19POLB | |
| SCHEMBL18650610 | 0.80 | BCHE (0.43) | MEN1KMT2APRMT1MAPT | |
| SCHEMBL27743755 | 0.79 | GAA (0.46) | MEN1KMT2AGAANPC1RAB9A | |
| SCHEMBL22770010 | 0.79 | GAA (0.46) | MEN1KMT2AGAANPC1RAB9A | |
| SCHEMBL8192075 | 0.79 | ALDH1A1 (0.51) | MEN1KMT2AGAANPC1ALOX5 | |
| SCHEMBL15528457 | 0.79 | MAPT (0.40) | MEN1KMT2AGAANPC1RAB9A | |
| SCHEMBL15600325 | 0.78 | GAA (0.43) | MEN1KMT2AGAANPC1RAB9A | |
| SCHEMBL27707038 | 0.78 | GAA (0.45) | MEN1KMT2AGAANPC1RAB9A | |
| SCHEMBL18654067 | 0.78 | GAA (0.45) | MEN1KMT2AGAANPC1RAB9A | |
| SCHEMBL1478008 | 0.78 | PRMT1 (0.47) | MEN1KMT2ANPC1RAB9APRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844656-A1 | SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS | Lupin Limited (IN) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013164773-A1 | SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS | LUPIN LIMITED (IN) | 2013-11-07 | — | — | WO | disclosed |