Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1532248 | 0.84 | KMT2A (0.59) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL2233218 | 0.84 | ALDH1A1 (0.56) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL8183254 | 0.83 | ALOX5 (0.62) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL30999886 | 0.83 | ALOX5 (0.62) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL6816134 | 0.81 | MEN1 (0.63) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL7308415 | 0.81 | MGLL (0.53) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL15528796 | 0.79 | MEN1 (0.41) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL31166020 | 0.79 | CYP1A2 (0.55) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL7913870 | 0.79 | CYP1A2 (0.55) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL14518047 | 0.79 | GAA (0.50) | ALDH1A1MAPTGAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1070490-C | Indole derivatives | GLAXO WELLCOME SPA (IT) | 2001-09-05 | — | — | CN | disclosed |
| US-6100289-A | ADMINISTERING AN ANALGESIC AMOUNT OF EXCITATORY AMINO ACID ANTAGONIST TO MAMMAL | GLAXO WELLCOME SPA (IT) | 2000-08-08 | — | — | US | disclosed |
| US-5962496-A | CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO WELLCOME SPA (IT) | 1999-10-05 | — | — | US | disclosed |
| US-5760059-A | ANTAGONISTS OF EXCITATORY AMINO ACIDS, TREATMENT OF NEURODEGENERATIVE DISEASES | GLAXO WELLCOME SPA (IT) | 1998-06-02 | — | — | US | disclosed |
| CN-1133042-A | Indole derivatives as NMDA antagonists | GLAXO SPA (IT) | 1996-10-09 | — | — | CN | disclosed |