Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 13/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552668 | 1.00 | PDK2 (0.57) | PDK2LTA4HHPGDNPC1ALDH1A1 | |
| SCHEMBL12337045 | 0.92 | PDK2 (0.60) | PDK2ALDH1A1 | |
| SCHEMBL134286 | 0.90 | PDK2 (0.58) | PDK2 | |
| SCHEMBL134285 | 0.90 | PDK2 (0.58) | PDK2 | |
| SCHEMBL29114 | 0.90 | PDK2 (0.58) | PDK2 | |
| SCHEMBL1552743 | 0.89 | PDK2 (0.66) | PDK2NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL133477 | 0.89 | PDK2 (0.66) | PDK2NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL13702054 | 0.87 | PDK2 (0.55) | PDK2 | |
| SCHEMBL12200611 | 0.85 | PDK2 (0.54) | PDK2 | |
| SCHEMBL13702055 | 0.85 | PDK2 (0.57) | PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188462-B2 | Spirobifluorene derivatives, their preparation and uses thereof | MERCK PATENT GMBH (DE) | 2012-05-29 | — | — | US | disclosed |
| EP-1534661-B1 | SPIROBIFLUORENE DERIVATIVES, THEIR PREPARATION AND USES THEREOF | MERCK PATENT GMBH (DE) | 2011-04-27 | — | — | EP | disclosed |
| US-20090302274-A1 | SPIROBIFLUORENE DERIVATIVES, THEIR PREPARATION AND USES THEREOF | MERCK PATENT GMBH (DE) | 2009-12-10 | — | — | US | disclosed |
| US-7557249-B2 | Spirobifluorene derivatives, their preparation and uses thereof | MERCK PATENT GMBH (DE) | 2009-07-07 | — | — | US | disclosed |
| US-20060006365-A1 | Spirobifluorene derivatives, their preparation and uses thereof | COVION ORGANIC SEMICONDUCTORS GMBH (DE) | 2006-01-12 | — | — | US | disclosed |
| EP-1534661-A1 | SPIROBIFLUORENE DERIVATIVES, THEIR PREPARATION AND USES THEREOF | Covion Organic Semiconductors GmbH (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004013080-A1 | SPIROBIFLUORENE DERIVATIVES, THEIR PREPARATION AND USES THEREOF | COVION ORGANIC SEMICONDUCTORS GMBH (DE) | 2004-02-12 | — | — | WO | disclosed |