Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 2/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22004131 | 0.83 | CCR2 (0.51) | CCR2 | |
| SCHEMBL23052955 | 0.83 | CCR2 (0.47) | CCR2DYRK1BKDM4EALDH1A1HPGD | |
| SCHEMBL4543516 | 0.80 | KDM4E (0.67) | CCR2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5823619 | 0.80 | MCL1 (0.62) | CCR2ALDH1A1MCL1LDHAGAA | |
| SCHEMBL2001537 | 0.78 | HSD17B10 (0.68) | ABCB11CCR2CLK1DYRK1ADYRK1B | |
| SCHEMBL1552728 | 0.76 | HRH3 (0.45) | CLK1DYRK1ADYRK1BCASRCYP2D6 | |
| SCHEMBL1552604 | 0.76 | SRD5A2 (0.72) | KDM4EALDH1A1HPGDHSD17B10F10 | |
| SCHEMBL1553069 | 0.74 | GPR35 (0.67) | ABCB11CCR2CLK1DYRK1ADYRK1B | |
| SCHEMBL20909821 | 0.73 | MCL1 (0.53) | CCR2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5319595 | 0.71 | PTGES (0.67) | ABCB11CCR2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968967-B1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2011-04-27 | — | — | EP | disclosed |
| US-7538101-B2 | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-20070123526-A1 | 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123526-A1 | 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives | MTNR1A, HTR1A, HRH4 | ABCB11 742/4885CCR2 524/4885CLK1 4001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.