Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28154396 | 0.95 | ACACB (0.47) | ACACBHSD11B1SPRNAMPTADAMTS5 | |
| SCHEMBL15528882 | 0.87 | ACACB (0.45) | ACACBHSD11B1SPRALDH1A1POLB | |
| SCHEMBL28154388 | 0.86 | HSD11B1 (0.48) | ACACBHSD11B1SPRNAMPTAPLNR | |
| SCHEMBL16228257 | 0.86 | NAMPT (0.53) | SMN1; SMN2NAMPTLMNAMAPTHTT | |
| SCHEMBL28155323 | 0.85 | HSD11B1 (0.46) | ACACBHSD11B1SPRALDH1A1POLB | |
| SCHEMBL28154383 | 0.85 | HSD11B1 (0.46) | ACACBHSD11B1SPRALDH1A1POLB | |
| SCHEMBL28154390 | 0.85 | HSD11B1 (0.48) | ACACBHSD11B1SPRALDH1A1POLB | |
| SCHEMBL28154387 | 0.84 | HSD11B1 (0.47) | ACACBHSD11B1SPRNAMPTAPLNR | |
| SCHEMBL28154393 | 0.84 | HSD11B1 (0.49) | ACACBHSD11B1SPRALDH1A1POLB | |
| SCHEMBL28154392 | 0.83 | HSD11B1 (0.48) | ACACBHSD11B1SPRALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104684906-B | Nampt inhibitor | 艾伯维公司 | 2017-06-09 | — | — | CN | claimed |
| EP-2852585-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-04-01 | — | — | EP | claimed |
| WO-2013170113-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | claimed |
| CN-104684906-B | Nampt inhibitor | 艾伯维公司 | 2017-06-09 | — | — | CN | disclosed |
| EP-2852585-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013170113-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | disclosed |