Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15529130 | 0.90 | KDM4E (0.48) | KDM4ESMN1; SMN2ALDH1A1HPGDMEN1 | |
| SCHEMBL15529231 | 0.86 | MAPT (0.50) | KDM4ESMN1; SMN2ALDH1A1HPGDMEN1 | |
| SCHEMBL27668372 | 0.75 | F2 (0.48) | KDM4ESMN1; SMN2ALDH1A1HPGDSTAT6 | |
| SCHEMBL3716881 | 0.72 | MAPT (0.70) | KDM4ESMN1; SMN2ALDH1A1HPGDSTAT6 | |
| SCHEMBL1585596 | 0.71 | KLKB1 (0.51) | MEN1KMT2ANPC1AURKARPS6KB1 | |
| SCHEMBL15529237 | 0.71 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL18979185 | 0.68 | MEN1 (0.86) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL15529196 | 0.68 | MEN1 (0.86) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7139105 | 0.68 | RPS6KB1 (0.49) | APPAURKARPS6KB1 | |
| SCHEMBL23827644 | 0.67 | NUDT1 (0.44) | STAT6MEN1KMT2AHTTESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846803-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | Anvyl, LLC (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013169889-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ANVYL LLC (US) | 2013-11-14 | — | — | WO | disclosed |