Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | ACACB | O00763 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16228527 | 0.85 | NAMPT (0.56) | NAMPT | |
| SCHEMBL28154396 | 0.85 | ACACB (0.47) | ADAMTS5NAMPTACACBHSD11B1SPR | |
| SCHEMBL28154384 | 0.84 | PDE10A (0.46) | ADAMTS5NAMPTACACBHSD11B1GRM5 | |
| SCHEMBL28154404 | 0.82 | CYP3A4 (0.48) | ADAMTS5NAMPTACACBHSD11B1SPR | |
| SCHEMBL28155324 | 0.82 | ACACB (0.47) | ADAMTS5NAMPTACACBHSD11B1SPR | |
| SCHEMBL28154378 | 0.82 | ACACB (0.46) | ADAMTS5ACACBHSD11B1SPRAPLNR | |
| SCHEMBL15529059 | 0.82 | NAMPT (0.58) | NAMPT | |
| SCHEMBL15379550 | 0.82 | NAMPT (0.48) | NAMPTEPHX2 | |
| SCHEMBL15529065 | 0.81 | ACACB (0.46) | ADAMTS5NAMPTACACBHSD11B1SPR | |
| SCHEMBL28154386 | 0.81 | HSD11B1 (0.47) | ADAMTS5NAMPTACACBHSD11B1SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852585-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-04-01 | — | — | EP | claimed |
| WO-2013170113-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | claimed |
| EP-2852585-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013170113-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | disclosed |