Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.62 |
| ▸ | HTR7 | P34969 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | UBE2N | P61088 | 1/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL449634 | 0.97 | ALDH1A1 (0.64) | PDE10AHTR7ALDH1A1MEN1CYP1A2 | |
| SCHEMBL451191 | 0.95 | ALDH1A1 (0.64) | PDE10AHTR7ALDH1A1MEN1CYP1A2 | |
| SCHEMBL449655 | 0.93 | POLB (0.61) | PDE10AHTR7ALDH1A1MEN1CYP1A2 | |
| SCHEMBL447996 | 0.92 | HTR7 (0.59) | PDE10AHTR7ALDH1A1MEN1CYP1A2 | |
| SCHEMBL452387 | 0.91 | HTR7 (0.59) | PDE10AHTR7ALDH1A1MEN1CYP1A2 | |
| SCHEMBL450020 | 0.88 | HTR7 (0.61) | PDE10AHTR7ALDH1A1MEN1CYP1A2 | |
| SCHEMBL449587 | 0.85 | SMN1; SMN2 (0.60) | PDE10AHTR7ALDH1A1MEN1CYP1A2 | |
| SCHEMBL453594 | 0.82 | ALDH1A1 (0.76) | PDE10AHTR7ALDH1A1MEN1CYP1A2 | |
| SCHEMBL452084 | 0.81 | PDE10A (0.60) | PDE10AHTR7ALDH1A1MEN1CYP1A2 | |
| SCHEMBL450538 | 0.81 | ALDH1A1 (0.66) | PDE10AHTR7ALDH1A1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521746-B1 | QUINAZOLINONE MODULATORS OF NUCLEAR RECEPTORS | X CEPTOR THERAPEUTICS INC (US) | 2011-04-27 | — | — | EP | disclosed |