Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12503631 | 0.94 | POLB (0.54) | POLBCYP2C19CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6069999 | 0.73 | LMNA (0.53) | PKMALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL27606285 | 0.71 | CHRNA7 (0.45) | CYP1A2 | |
| SCHEMBL12503629 | 0.70 | SMN1; SMN2 (0.45) | PKMTSHRKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7011026 | 0.69 | TSHR (0.74) | POLBCYP2C19CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10492340 | 0.67 | CYP11B1 (0.46) | CYP1A2 | |
| SCHEMBL11174344 | 0.67 | SMN1; SMN2 (0.69) | POLBTSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL10492186 | 0.67 | HTT (0.47) | CYP1A2ALDH1A1HTTL3MBTL1 | |
| SCHEMBL27606289 | 0.67 | MPO (0.43) | CYP1A2PKMALDH1A1 | |
| SCHEMBL18725052 | 0.66 | KEAP1 (0.71) | POLBCYP2C19CYP1A2CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013170191-A1 | METHODS OF USING ANTAGONISTS OF NAD BIOSYNTHESIS FROM NICOTINAMIDE | GENENTECH, INC. (US) | 2013-11-14 | — | — | WO | disclosed |