Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | PER2 | O15055 | 11/20 | 0.56 |
| ▸ | CRY1 | Q16526 | 8/20 | 0.56 |
| ▸ | CRY2 | Q49AN0 | 8/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15530023 | 1.00 | BACE1 (0.63) | BACE1POLBPER2CRY1CRY2 | |
| SCHEMBL20450183 | 1.00 | BACE1 (0.63) | BACE1POLBPER2CRY1CRY2 | |
| SCHEMBL20450132 | 0.96 | POLB (0.63) | BACE1POLBPER2CRY1CRY2 | |
| SCHEMBL20450206 | 0.96 | POLB (0.63) | BACE1POLBPER2CRY1CRY2 | |
| SCHEMBL20450177 | 0.96 | POLB (0.63) | BACE1POLBPER2CRY1CRY2 | |
| SCHEMBL20450179 | 0.81 | CRY2 (0.60) | PER2CRY1CRY2 | |
| SCHEMBL20450152 | 0.81 | CRY1 (0.60) | BACE1POLBPER2CRY1CRY2 | |
| SCHEMBL20450148 | 0.81 | CRY2 (0.60) | PER2CRY1CRY2 | |
| SCHEMBL20450140 | 0.80 | CRY2 (0.63) | PER2CRY1CRY2 | |
| SCHEMBL20450173 | 0.80 | PER2 (0.58) | BACE1POLBPER2CRY1CRY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855458-B1 | CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS | RESET THERAPEUTICS INC (US) | 2018-08-08 | — | — | EP | claimed |
| EP-2855458-A1 | CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS | Reset Therapeutics, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013170186-A1 | CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS | RESET THERAPEUTICS, INC. (US) | 2013-11-14 | — | — | WO | disclosed |