Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.69 |
| ▸ | PDE4A | P27815 | 10/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.69 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526223 | 0.99 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4CGFER | |
| SCHEMBL7417915 | 0.82 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CGFER | |
| Piclamilast SCHEMBL26573 | 0.82 | PDE4D (1.00) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7421422 | 0.81 | PDE4D (0.79) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7335911 | 0.81 | PDE4D (0.98) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL69331 | 0.80 | PDE4D (0.68) | PDE4BPDE4DPDE4APDE4CGFER | |
| SCHEMBL72555 | 0.79 | PDE4D (0.73) | PDE4BPDE4DPDE4APDE4CGFER | |
| SCHEMBL7542303 | 0.79 | GFER (0.48) | PDE4BPDE4DPDE4APDE4CGFER | |
| SCHEMBL71427 | 0.78 | PDE4B (0.66) | PDE4BPDE4DPDE4APDE4CGFER | |
| SCHEMBL70380 | 0.77 | PDE4D (0.72) | PDE4BPDE4DPDE4APDE4CGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015068142-A2 | COMPOSITIONS, PROCESS OF PREPARATION OF SAID COMPOSITIONS, USES AND METHOD OF MANAGEMENT OF MYELOPROLIFERATIVE DISORDER | CELLWORKS GROUP, INC. (US) | 2015-05-14 | — | — | WO | disclosed |
| EP-2846788-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | Akron Molecules AG (AT) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013167743-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | AKRON MOLECULES GMBH (AT) | 2013-11-14 | — | — | WO | disclosed |